abstract：:Nanooncology, the application of nanobiotechnology to the management of cancer, is currently the most important chapter of nanomedicine. Nanobiotechnology has refined and extended the limits of molecular diagnosis of cancer, for example, through the use of gold nanoparticles and quantum dots. Nanobiotechnology has als...

journal_title：BMC medicine

authors： Jain KK

更新日期：2010-12-13 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is of clinical and public health importance as it is very common, affecting up to one in five women of reproductive age. It has significant and diverse clinical implications including reproductive (infertility, hyperandrogenism, hirsutism), metabolic (insulin resistance, impaired gluco...

journal_title：BMC medicine

authors： Teede H,Deeks A,Moran L

更新日期：2010-06-30 00:00:00

abstract：BACKGROUND:Clinical pathways are tools used to guide evidence-based healthcare that have been implemented internationally since the 1980s. However, there is widespread lack of agreement on the impact of clinical pathways on hospital resources and patient outcomes. This can be partially attributed to the confusion for b...

journal_title：BMC medicine

authors： Kinsman L,Rotter T,James E,Snow P,Willis J

更新日期：2010-05-27 00:00:00

abstract：BACKGROUND:Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unknown. To investigate the role of the normal breast microenvironment on breast cancer cell tumorigenic...

journal_title：BMC medicine

authors： Fleming JM,Miller TC,Quinones M,Xiao Z,Xu X,Meyer MJ,Ginsburg E,Veenstra TD,Vonderhaar BK

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:Inflammatory cytokines play a crucial role in coronary artery disease (CAD). We investigated the association between 48 coding and three non-coding single nucleotide polymorphisms (SNPs) from 35 inflammatory genes and the development of CAD, using a large discordant sibship collection (2699 individuals in 89...

journal_title：BMC medicine

authors： Brown BD,Nsengimana J,Barrett JH,Lawrence RA,Steiner L,Cheng S,Bishop DT,Samani NJ,Ball SG,Balmforth AJ,Hall AS

更新日期：2010-01-13 00:00:00

abstract：BACKGROUND:Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effects of IGF-I on cancer cells and stromal cells separately. METHODS:We used an ex vivo culture model ...

journal_title：BMC medicine

authors： Rajski M,Zanetti-Dällenbach R,Vogel B,Herrmann R,Rochlitz C,Buess M

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:Bangladesh, India and Nepal are working towards the elimination of visceral leishmaniasis (VL) by 2015. In 2005 the World Health Organization/Training in Tropical Diseases launched an implementation research programme to support integrated vector management for the elimination of VL from Bangladesh, India an...

journal_title：BMC medicine

authors： Joshi AB,Das ML,Akhter S,Chowdhury R,Mondal D,Kumar V,Das P,Kroeger A,Boelaert M,Petzold M

更新日期：2009-10-05 00:00:00

abstract：BACKGROUND:Schools are the most frequent target for intervention programs aimed at preventing child obesity; however, the overall effectiveness of these programs has been limited. It has therefore been recommended that interventions target multiple ecological levels (community, family, school and individual) to have gr...

journal_title：BMC medicine

authors： Gentile DA,Welk G,Eisenmann JC,Reimer RA,Walsh DA,Russell DW,Callahan R,Walsh M,Strickland S,Fritz K

更新日期：2009-09-18 00:00:00

abstract：BACKGROUND:The treatment of patients with haematological malignancies by means of haematopoietic stem cell transplantation (HSCT) is often accompanied by life threatening infections. With emerging antimicrobial resistance there is an increased need for new agents, with a beneficial safety profile. Therefore we evaluate...

journal_title：BMC medicine

authors： Velden WJ,van Iersel TM,Blijlevens NM,Donnelly JP

更新日期：2009-09-08 00:00:00

abstract：:The approval of sorafenib and active development of many other molecularly targeted agents in hepatocellular carcinoma (HCC) have presented a challenge to understand the mechanism of action of sorafenib and identify predictive biomarkers to select patients more likely to benefit from sorafenib. The preclinical study b...

journal_title：BMC medicine

authors： Zhu AX

更新日期：2009-08-24 00:00:00

abstract：BACKGROUND:Despite the worldwide increasing burden of diabetes, there has been no corresponding scale-up of treatment in developing countries and limited evidence of program effectiveness. In 2002, in collaboration with the Ministry of Health of Cambodia, Médecins Sans Frontières initiated an outpatient program of subs...

journal_title：BMC medicine

authors： Raguenaud ME,Isaakidis P,Reid T,Chy S,Keuky L,Arellano G,Van Damme W

更新日期：2009-07-14 00:00:00

abstract：:Proteinuria is a defining criterion for the diagnosis of pre-eclampsia. The amount of protein lost per day has been thought by some to predict both maternal and fetal outcome. The systematic review of 16 primary papers including over 6700 patients by Thangaratinam and colleagues published this month in BMC Medicine su...

journal_title：BMC medicine

authors： Hofmeyr GJ,Belfort M

更新日期：2009-03-24 00:00:00

abstract：:Alzheimer's disease is a devastating neurological disorder that affects more than 37 million people worldwide. The economic burden of Alzheimer's disease is massive; in the United States alone, the estimated direct and indirect annual cost of patient care is at least $100 billion. Current FDA-approved drugs for Alzhei...

journal_title：BMC medicine

authors： Rafii MS,Aisen PS

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Vertical and horizontal trust, as dimensions of social capital, may be important determinants of health. As mass media campaigns have been used extensively to promote healthy lifestyles and convey health-related information, high levels of individual trust in the media may facilitate the success of such camp...

journal_title：BMC medicine

authors： Tokuda Y,Fujii S,Jimba M,Inoguchi T

更新日期：2009-01-22 00:00:00

abstract：BACKGROUND:Use of fenfluramines for weight loss has been associated with the development of characteristic plaques on cardiac valves causing regurgitation. However, previously published studies of exposure to fenfluramines have been limited by relatively small sample size, short duration of follow-up, and the lack of a...

journal_title：BMC medicine

authors： Dahl CF,Allen MR,Urie PM,Hopkins PN

更新日期：2008-11-06 00:00:00

abstract：BACKGROUND:Migraine aura may be difficult to differentiate from transient ischemic attacks and other transient neurological disorders in pregnant women. The aims of the present study were to investigate and diagnose all pregnant women with transient neurological disorders of suspected central nervous system origin, and...

journal_title：BMC medicine

authors： Ertresvg JM,Stovner LJ,Kvavik LE,Johnsen HJ,Zwart JA,Helde G,Bovim G

更新日期：2007-07-17 00:00:00

abstract：BACKGROUND:Although vaccination has been proved to be a safe, efficacious, and cost-effective intervention, immunisation rates remain suboptimal in many European countries, resulting in poor control of many vaccine-preventable diseases. DISCUSSION:The Summit of Independent European Vaccination Experts focused on the p...

journal_title：BMC medicine

authors： Schmitt HJ,Booy R,Aston R,Van Damme P,Schumacher RF,Campins M,Rodrigo C,Heikkinen T,Weil-Olivier C,Finn A,Olcén P,Fedson D,Peltola H

更新日期：2007-05-29 00:00:00

abstract：BACKGROUND:Recent reviews on placebo effects in clinical trials suggest that objective changes following placebo treatments may not exist or, at least, have been considerably overestimated. However, the possibility that yet unidentified subsets of parameters are responsive to placebo treatments has not been taken into ...

journal_title：BMC medicine

authors： Meissner K,Distel H,Mitzdorf U

更新日期：2007-03-19 00:00:00

abstract：BACKGROUND:Pendred syndrome, an autosomal-recessive disorder characterized by deafness and goiter, is caused by a mutation of SLC26A4, which codes for the anion exchanger pendrin. We investigated the relationship between pendrin expression and deafness using mice that have (Slc26a4+/+ or Slc26a4+/-) or lack (Slc26a4-/-...

journal_title：BMC medicine

authors： Jabba SV,Oelke A,Singh R,Maganti RJ,Fleming S,Wall SM,Everett LA,Green ED,Wangemann P

更新日期：2006-12-22 00:00:00

abstract：BACKGROUND:Skin toxicity is a common side effect of radiotherapy for solid tumors. Its management can cause treatment gaps and thus can impair cancer treatment. At present, in many countries no standard recommendation for treatment of skin during radiotherapy exists. In this study, we explored the effect of topically-a...

journal_title：BMC medicine

authors： Pajonk F,Riedisser A,Henke M,McBride WH,Fiebich B

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Israeli citizens have been exposed to intense and ongoing terrorism since September 2000. We previously studied the mental health impact of terrorism on the Israeli population (Bleich et al., 2002), however the long-term impact of ongoing terrorism has not yet been examined. The present study evaluated the p...

journal_title：BMC medicine

authors： Bleich A,Gelkopf M,Melamed Y,Solomon Z

更新日期：2006-08-27 00:00:00

abstract：BACKGROUND:Electronic mail (email) has the potential to improve communication between physicians and patients. METHODS:We conducted two research studies in a family practice setting: 1) a brief, anonymous patient survey of a convenience sample to determine the number of clinic patients receptive to communicating with ...

journal_title：BMC medicine

authors： Virji A,Yarnall KS,Krause KM,Pollak KI,Scannell MA,Gradison M,Østbye T

更新日期：2006-08-15 00:00:00

abstract：BACKGROUND:The aim of the current study was to assess the antidepressant efficacy and safety of Hypericum perforatum (St. John's wort) extract WS 5570 at doses of 600 mg/day in a single dose and 1200 mg/day in two doses. METHODS:The participants in this double-blind, randomized, placebo-controlled, multi-center clinic...

journal_title：BMC medicine

authors： Kasper S,Anghelescu IG,Szegedi A,Dienel A,Kieser M

更新日期：2006-06-23 00:00:00

abstract：BACKGROUND:There has been concern that the incidence of autism and other pervasive developmental disorders (PDDs) is increasing. Previous studies have been smaller, restricted to autism (excluding other pervasive developmental disorders such as Asperger's syndrome), included boys only, or have not been based on a natio...

journal_title：BMC medicine

authors： Smeeth L,Cook C,Fombonne PE,Heavey L,Rodrigues LC,Smith PG,Hall AJ

更新日期：2004-11-09 00:00:00

abstract：BACKGROUND:Contrast-induced nephropathy is an important cause of acute renal failure. We assess the efficacy of acetylcysteine for prevention of contrast-induced nephropathy among patients undergoing intravascular angiography. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials c...

journal_title：BMC medicine

authors： Bagshaw SM,Ghali WA

更新日期：2004-10-22 00:00:00

abstract：BACKGROUND:The major psychoactive cannabinoid compound of marijuana, delta-9 tetrahydrocannabinol (THC), has been shown to modulate immune responses and lymphocyte function. After primary infection the viral DNA genome of gamma herpesviruses persists in lymphoid cell nuclei in a latent episomal circular form. In respon...

journal_title：BMC medicine

authors： Medveczky MM,Sherwood TA,Klein TW,Friedman H,Medveczky PG

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:We conducted this analysis to determine i) which journals publish high-quality, clinically relevant studies in internal medicine, general/family practice, general practice nursing, and mental health; and ii) the proportion of clinically relevant articles in each journal. METHODS:We performed an analytic sur...

journal_title：BMC medicine

authors： McKibbon KA,Wilczynski NL,Haynes RB

更新日期：2004-09-06 00:00:00

abstract：BACKGROUND:Pendred syndrome, a common autosomal-recessive disorder characterized by congenital deafness and goiter, is caused by mutations of SLC26A4, which codes for pendrin. We investigated the relationship between pendrin and deafness using mice that have (Slc26a4+/+) or lack a complete Slc26a4 gene (Slc26a4-/-). M...

journal_title：BMC medicine

authors： Wangemann P,Itza EM,Albrecht B,Wu T,Jabba SV,Maganti RJ,Lee JH,Everett LA,Wall SM,Royaux IE,Green ED,Marcus DC

更新日期：2004-08-20 00:00:00

abstract：BACKGROUND:The study investigated the extent to which approaches to work, workplace climate, stress, burnout and satisfaction with medicine as a career in doctors aged about thirty are predicted by measures of learning style and personality measured five to twelve years earlier when the doctors were applicants to medic...

journal_title：BMC medicine

authors： McManus IC,Keeling A,Paice E

更新日期：2004-08-18 00:00:00

abstract：BACKGROUND:Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol trafficking characterized by increased plasma plant sterol levels. Based upo...

journal_title：BMC medicine

authors： Klett EL,Lu K,Kosters A,Vink E,Lee MH,Altenburg M,Shefer S,Batta AK,Yu H,Chen J,Klein R,Looije N,Oude-Elferink R,Groen AK,Maeda N,Salen G,Patel SB

更新日期：2004-03-24 00:00:00

abstract：BACKGROUND:To help design population-based pediatric palliative care services, we sought to describe the hospital care received in the last year of life by children and young adults who died. We also determined the proportion with complex chronic conditions (CCCs) and tested whether the use of hospital services increas...

journal_title：BMC medicine

authors： Feudtner C,DiGiuseppe DL,Neff JM

更新日期：2003-12-23 00:00:00